The Nature and Time Course of Cortical Activation Following Subthalamic Stimulation in Parkinson's Disease
Identifieur interne : 001B21 ( Main/Exploration ); précédent : 001B20; suivant : 001B22The Nature and Time Course of Cortical Activation Following Subthalamic Stimulation in Parkinson's Disease
Auteurs : Renju Kuriakose [Canada] ; Utpal Saha [Canada] ; Gabriel Castillo [Canada] ; Kaviraja Udupa [Canada] ; Zhen Ni [Canada] ; Carolyn Gunraj [Canada] ; Filomena Mazzella [Canada] ; Clement Hamani [Canada] ; Anthony E. Lang [Canada] ; Elena Moro [Canada] ; Andres M. Lozano [Canada] ; Mojgan Hodaie [Canada] ; Robert Chen [Canada]Source :
- Cerebral Cortex [ 1047-3211 ] ; 2010-08.
English descriptors
- KwdEn :
- Action Potentials (physiology), Aged, Deep Brain Stimulation, Evoked Potentials, Motor (physiology), Humans, Middle Aged, Motor Cortex (anatomy & histology), Motor Cortex (physiology), Neural Conduction (physiology), Neural Pathways (physiology), Neurons, Efferent (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Pyramidal Tracts (physiology), Reaction Time (physiology), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (physiology), Synaptic Transmission (physiology), Transcranial Magnetic Stimulation.
- MESH :
- anatomy & histology : Motor Cortex, Subthalamic Nucleus.
- physiology : Action Potentials, Evoked Potentials, Motor, Motor Cortex, Neural Conduction, Neural Pathways, Neurons, Efferent, Pyramidal Tracts, Reaction Time, Subthalamic Nucleus, Synaptic Transmission.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Deep Brain Stimulation, Humans, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
We studied the time course and nature of interactions between the subthalamic nucleus (STN) and the motor cortex in 8 Parkinson disease (PD) patients with chronically implanted STN deep-brain stimulation (DBS) electrodes. We first identified the cortical evoked potentials following STN stimulation. The most consistent potential was positive wave with peak latency of 22.2 1.2 ms from stimulation of clinically effective contacts. We then stimulated the motor cortex with transcranial magnetic stimulation (TMS) at 215 ms and at the latency of the evoked potential ( 23 ms) following STN DBS. TMS induced currents in 3 directions: lateralmedial (LM) direction activated corticospinal axons directly, posterioranterior (PA), and anteriorposterior (AP) directions activated corticospinal neurons transynaptically. Motor-evoked potentials (MEP) elicited by AP and PA TMS were facilitated at short (24 ms) and medium latencies (2124 ms). However, MEPs elicited by LM TMS were not modified by STN DBS. Short-latency antidromic stimulation of the corticosubthalamic projections and medium latency transmission likely through the basal gangliathalamocortical circuit led to cortical evoked potentials and increased motor cortex excitability at specific intervals following STN stimulation at clinically effective contacts. Cortical activation may be related to the clinical effects of STN DBS in PD.
Url:
DOI: 10.1093/cercor/bhp269
Affiliations:
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Cortical Activation Following Subthalamic Stimulation in Parkinson's Disease</title><author><name sortKey="Kuriakose, Renju" sort="Kuriakose, Renju" uniqKey="Kuriakose R" first="Renju" last="Kuriakose">Renju Kuriakose</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Saha, Utpal" sort="Saha, Utpal" uniqKey="Saha U" first="Utpal" last="Saha">Utpal Saha</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Castillo, Gabriel" sort="Castillo, Gabriel" uniqKey="Castillo G" first="Gabriel" last="Castillo">Gabriel Castillo</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Udupa, Kaviraja" sort="Udupa, Kaviraja" uniqKey="Udupa K" first="Kaviraja" last="Udupa">Kaviraja Udupa</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Cerebral Cortex</title><idno type="ISSN">1047-3211</idno><idno type="eISSN">1460-2199</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-08">2010-08</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1926">1926</biblScope><biblScope unit="page" to="1936">1936</biblScope></imprint><idno type="ISSN">1047-3211</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1047-3211</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Evoked Potentials, Motor (physiology)</term><term>Humans</term><term>Middle Aged</term><term>Motor Cortex (anatomy & histology)</term><term>Motor Cortex (physiology)</term><term>Neural Conduction (physiology)</term><term>Neural Pathways (physiology)</term><term>Neurons, Efferent (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Pyramidal Tracts (physiology)</term><term>Reaction Time (physiology)</term><term>Subthalamic Nucleus (anatomy & histology)</term><term>Subthalamic Nucleus (physiology)</term><term>Synaptic Transmission (physiology)</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Motor Cortex</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neural Conduction</term><term>Neural Pathways</term><term>Neurons, Efferent</term><term>Pyramidal Tracts</term><term>Reaction Time</term><term>Subthalamic Nucleus</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Humans</term><term>Middle Aged</term><term>Transcranial Magnetic Stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">We studied the time course and nature of interactions between the subthalamic nucleus (STN) and the motor cortex in 8 Parkinson disease (PD) patients with chronically implanted STN deep-brain stimulation (DBS) electrodes. We first identified the cortical evoked potentials following STN stimulation. The most consistent potential was positive wave with peak latency of 22.2 1.2 ms from stimulation of clinically effective contacts. We then stimulated the motor cortex with transcranial magnetic stimulation (TMS) at 215 ms and at the latency of the evoked potential ( 23 ms) following STN DBS. TMS induced currents in 3 directions: lateralmedial (LM) direction activated corticospinal axons directly, posterioranterior (PA), and anteriorposterior (AP) directions activated corticospinal neurons transynaptically. Motor-evoked potentials (MEP) elicited by AP and PA TMS were facilitated at short (24 ms) and medium latencies (2124 ms). However, MEPs elicited by LM TMS were not modified by STN DBS. Short-latency antidromic stimulation of the corticosubthalamic projections and medium latency transmission likely through the basal gangliathalamocortical circuit led to cortical evoked potentials and increased motor cortex excitability at specific intervals following STN stimulation at clinically effective contacts. Cortical activation may be related to the clinical effects of STN DBS in PD.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Kuriakose, Renju" sort="Kuriakose, Renju" uniqKey="Kuriakose R" first="Renju" last="Kuriakose">Renju Kuriakose</name></region><name sortKey="Castillo, Gabriel" sort="Castillo, Gabriel" uniqKey="Castillo G" first="Gabriel" last="Castillo">Gabriel Castillo</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Gunraj, Carolyn" sort="Gunraj, Carolyn" uniqKey="Gunraj C" first="Carolyn" last="Gunraj">Carolyn Gunraj</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name><name sortKey="Kuriakose, Renju" sort="Kuriakose, Renju" uniqKey="Kuriakose R" first="Renju" last="Kuriakose">Renju Kuriakose</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Ni, Zhen" sort="Ni, Zhen" uniqKey="Ni Z" first="Zhen" last="Ni">Zhen Ni</name><name sortKey="Saha, Utpal" sort="Saha, Utpal" uniqKey="Saha U" first="Utpal" last="Saha">Utpal Saha</name><name sortKey="Udupa, Kaviraja" sort="Udupa, Kaviraja" uniqKey="Udupa K" first="Kaviraja" last="Udupa">Kaviraja Udupa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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